Application | Comment | Organism |
---|---|---|
medicine | prostate-specific antigen is identified as a useful serum marker for assessing patients with prostate cancer during their follow-up. It is approved as a tool for detecting the disease in men aged over 50 years. There are limitations of a single prostate-specific antigen measurement, i.e. its low sensitivity and specificity in detecting prostate cancer, which may lead to the over-detection of cancers that pose little threat to health and/or life. Prostate-specific antigen kinetics (prostate-specific antigen velocity, doubling-time, half-time and progression) may be used to predict the outcome in both localized and advanced prostate cancer. Limitations of all prostate-specific antigen kinetics is the choice of many methods for calculation that can result in considerable variation in prediction and even in errors in patient management | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | prostate-specific antigen shows low specificity, besides increased levels in prostate cancer, prostate-specific antigen levels are also increased in benign prostatic hyperplasia, and in general inflammatory responses. Shows low sensitivity, prostate-specific antigen levels are highly variable over time, prostate-specific antigen poorly distinguishes indolent from aggressive cancers | Homo sapiens | - |
prostate | - |
Homo sapiens | - |
semen | - |
Homo sapiens | - |
serum | in the serum of patients with prostate cancer | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
prostate-specific antigen | - |
Homo sapiens |
PSA | - |
Homo sapiens |